A meta analysis of the relation between TNF - α G 308 A gene polymorphism and heart disease
نویسندگان
چکیده
Objective: To evaluate the correlation of TNF-α G308A polymorphism and heart disease (HD) using meta-analysis. Methods: Databases including PubMed, EMbase, CNKI and WanFang Data were searched (2003 to 2013). Results: A total of 5 studies were included, involving 539 heart disease (HD) cases and 624 controls. The results of meta-analysis according to recessive genetic model of TNF-α G308A showed that there were significant differences in RHD risk between the AA genotype carriers and the GA+GG genotype carries (OR=5.06, 95%CI 2.15 to 11.89, P=0.0002). Conclusion: Current evidence shows that TNF-α G308A polymorphism is related to RHD, and the AA geno-type carriers tend to face an increasing RHD risk. [Li Yang, Chunjiang Fu, Xukai Wang, Chunyu Zeng. A meta analysis of the relation between TNF-α G308A gene polymorphism and heart disease. Life Sci J 2014;11(4):204-206]. (ISSN:1097-8135). http://www.lifesciencesite.com. 30
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